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without doing more harm in the long run than it does good in the short. Such a drug must be potent in minute doses and synthesizable. If it does not possess these qualities, its production, like that of wine, beer, spirits and tobacco will interfere with the raising of indispensable food and fibers. It must be less toxic than opium or cocaine, less likely to produce undesirable social consequences than alcohol or the barbiturates, less inimical to heart and lungs than the tars and nicotine of cigarettes. And, on the positive side, it should produce changes in consciousness more interesting, more intrinsically valuable than mere sedation or dreaminess, delusions of omnipotence or release from inhibition. To most people, mescalin is almost completely innocuous. Unlike alcohol, it does not drive the taker into the kind of uninhibited action which results in brawls, crimes of violence and traffic accidents. A man under the influence of mescalin quietly minds his own business. Moreover, the business he minds is an experience of the most enlightening kind, which does not have to be paid for (and this is surely important) by a compensatory hangover. Of the long-range consequences of regular mescalin taking we know very little. The Indians who consume peyote buttons do not seem to be physically or morally degraded by the habit. However, the available evidence is still scarce and sketchy.* Although obviously superior to cocaine, opium, alcohol and tobacco, mescalin is not yet the ideal drug. Along with the happily transfigured majority of mescalin takers there is a minority that finds in the drug only hell or purgatory. Moreover, for a drug that is to be used, like alcohol, for general consumption, its effects last for an inconveniently long time. But chemistry and physiology are capable nowadays of practically anything. If the psychologists and sociologists will define the ideal, the neurologists and pharmacologists can be relied upon to discover the means whereby that ideal can be realized or at least (for perhaps this kind of ideal can never, in the very nature of things, be fully realized) more nearly approached than in the wine-bibbing past, the whiskydrinking, marijuana-smoking and barbiturate-swallowing present. The urge to transcend self-conscious selfhood is, as I have said, a principal appetite of the soul. When, for whatever reason, men and women fail to transcend themselves by means of worship, good works and spiritual exercises, they are apt to resort to religion's chemical surrogates-alcohol and "goof pills" in the modern West, alcohol and opium in the East, hashish in the Mohammedan world, alcohol and marijuana in Central America, alcohol and coca in the Andes, alcohol and the barbiturates in the more up-to-date regions of South America. In Poisons Sacres, Ivresses Divines Philippe de Felice has written at length and with a wealth of documentation on the immemorial connection between religion and the taking of drugs. Here, in summary or in direct quotation, are his conclusions. The employment for religious purposes of toxic substances is "extraordinarily widespread.... The practices studied in this volume can be observed in every region of the earth, among primitives no less than among those who have reached a high pitch of civilization. We are therefore dealing not with exceptional facts, which might justifiably be overlooked, but with a general and, in the widest sense of the word, a human phenomenon, the kind of phenomenon which cannot be disregarded by anyone who is trying to discover what religion is, and what are the deep needs which it must satisfy." Ideally, everyone should be able to find self-transcendence in some form of pure or applied religion. In practice it seems very unlikely that this hoped for consummation will ever be realized. There are, and doubtless there always will be, good churchmen and good churchwomen for whom, unfortunately, piety is not enough. The late G. K. Chesterton, who wrote at least as lyrically of drink as of devotion, may serve as their eloquent spokesman. The modern churches, with some exceptions among the Protestant denominations, tolerate alcohol; but even the most tolerant have made no attempt to convert the drug to Christianity, or to sacramentalize its use. The pious drinker is forced to take his religion in one compartment, his religionsurrogate in another. And perhaps this is inevitable. Drinking cannot be sacramentalized except in