COULSON & CO. respectfully announce, that, with improved facilities, and larger capital, they are now producing a very superior grade of phosogenic and protoplasmic remedies, and at greatly reduced prices, and of a finer quality than is possible by any other medico-chemical house in the country; besides which, they own the sole rights of the processes on the continent. The improved Nervo-Vital remedies will hereafter be sold at the following (considering the enormous cost of their production) exceedingly low scale of prices : Concentrated Piiosogen, absolutely pure, the most perfect nervous invigorant in the world, for physicians’ and druggists’ use, in pound flasks; $5 each, per dozen $40. Piiosodyn, pure, a splendid remedy for all forms of nervous disease, exhaustion, debility, braintrouble, mental wandering, and unequalled in complaints peculiar to females and persons of sedentary habits, per pound flasks $5, per dozen $36. Neurine, pure, a magnificent chemioal triumph; a perfect agent for the cure of Dyspepsia, and blood troubles, and the purest tonic invigorant stomachic cordial, per flask $2 50, per dozen $20. Barosmyn, an excellent agent, and unequalled for all cases of kidney and bladder difficulties, the diosma crenata being skilfully combined with phymylle, glycerole, and liypophosphite of soda; price, per pound flask $5, per dozen $36. COULSON & CO. also prepare an Alexipliarmic remedy, believed to be a perfect antidote to all poisonous taint in the blood, from a simple rheum to the most inveterate scrofula; price $5; per dozen $36. Ciilorylle, for the use of consumptives and delicate anaemic cases; per flask $5, per dozen $36. We also prepare a fine Rheumatic Remedy, superior to any yet evolved by medico-chemical research; - price $5, per dozen $36. None of these celebrated agents are in any sense “Patent Medicines,” but a series of well-tested medical agents, believed to be superior to all others in existence for their peculiar specialties. COULSON & CO. are prepared to supply all orders, and to give territorial rights for the exclusive sale and use of their preparations, and to give special instructions to those who desire to make nervous diseases in all their forms a specialty; said instructions embracing an entirely new system of gynaecology, enabling the physician to treat female complaints, and obstinate renal and brain diseases, with a power and success never attained before the discovery and use of the above series of Protoplasmic remedials. LABORATORY AND CENTRAL OFFICE, P. O. Box 3,352, Boston, Mass. COULSON AND COMPANY, Special Chemists, and Manufacturers of Nervo- Vital Bemedials, 176 if I